FondaparinSodiumM;Boitsebiso ba Fondaparinux SodiumM;Fondaparinux sodium N-4;
FondaparinSodiumM;Boitsebiso ba Fondaparinux SodiumM;Fondaparinux sodium N-4;
Fondaparinux Biological Activity
| Hlalosa | Fondaparinux sodium ke antithrombin-dependent factor Xa inhibitor. |
| Tse amanangLihlopha | tsela ea lipontšo >> Li-enzyme/proteases >> Factor Xa Research libaka >> Mafu a pelo |
| Sepheo | Factor Xa[1] |
| In vitrolithuto | Fondaparinux sodium ke anticoagulant ea pele e ncha e khethang ho khetha Xa.Bakeng sa Fondaparinux, boleng ba IC50 (anti-Xa IU/ml) ea li-monocyte tse kentsoeng (ac-M) ke 0.59±0.05, le likaroloana tse nkiloeng ho monocyte (MMP) ke 0.17±0.03 [2]. |
| Ka vivolipatlisiso | Fondaparinux sodium e na le profil ea pharmacokinetic e itšetlehileng ka tekanyetso, e fanang ka karabelo e ka tsejoang esale pele.Fondaparinux sodium e na le 100% bioavailability, e na le ts'ebetso e potlakileng, e na le halofo ea bophelo ea lihora tse 14 ho isa ho tse 16, 'me e ka tsoela pele ho hanyetsa thrombosis nakong ea lihora tse 24.Setlhare ha se ame nako ea prothrombin kapa nako e kentsoeng ea karolo ea thromboplastin, ebile ha e ame tšebetso ea liplatelete kapa ho kopanya [1]. |
| Litšupiso | [1].Bauer KA.le al.Fondaparinux sodium: inhibitor e khethang ea factor Xa.Am J Health Syst Pharm.2001 Nov 1;58 Tlatsetso 2:S14-7.[2].Ben-Hadj-Khalifa S, le ba bang.Phapang ea coagulation inhibitory phello ea fondaparinux, enoxaparin le heparin e sa tsitsang mefuteng ea lisele tsa tlhahiso ea thrombin.Mali a Coagul Fibrinolysis.2011 Jul;22(5):369-73. |
Lik'hemik'hale le thepa ea 'mele ea Fondaparinux
| Mokhoa oa limolek'hule | C31H53N3Na10O49S8 |
| Boima ba molek'hule | 1738.16 |
| PSA | 900.82000 |
Fondaparinux ke mofuta o mocha oa moriana oa antithrombotic o amohetsoeng ke FDA kamora heparin le heparin e tlase ea boima ba molek'hule bakeng sa kalafo le thibelo ea mefuta e fapaneng ea arteriovenous thrombosis.
Lipontšo: Fondaparinux e sebelisetsoa bakuli ba etsoang opereishene e kholo ea masapo ea maoto le matsoho a ka tlaase, joalo ka ho robeha ha letheka, ho buuoa ka lengole le leholo kapa ho fetola letheka, ho thibela venous thromboembolism.E sebelisetsoa ho phekola bakuli ba nang le angina e sa tsitsang kapa ba se nang ST-segment elevation myocardial infarction ba kenang ka potlako (<120 metsotso) kalafo e hlaselang (PCI) ntle le pontšo.E sebelisoa bakeng sa kalafo ea bakuli ba nang le ST-segment elevation myocardial infarction ba sebelisang thrombolysis kapa qalong ba sa fumaneng mefuta e meng ea kalafo ea reperfusion.
1) Kholiso e tsoelang pele ea 'maraka ea Glaxo e tla e beha boemong ba mantlha ba lithethefatsi tseleng e latelang ea bongaka ea Lekala la Bophelo, phetoho ea theko ea Khomishene ea Naha ea Nts'etsopele le Phetoho, le inshorense ea bongaka ea Lekala la People's Insurance.
A、Sehlahisoa ha se so kene ho inshorense ea bongaka ea naha.Ka 2010, tokiso ea inshorense ea bongaka e sa tsoa kenya inshorense ea lehae ea liprofinse tse 16.Lithekiso li boemong ba pele 'me butle-butle li tla nka sebaka sa' maraka oa heparin oa boima bo tlase ba limolek'hule;liprofinse tsa inshorense ea bongaka: Shaanxi, Shanxi, Inner Mongolia, Liaoning, Tibet, Yunnan, Guangdong , Guangxi, Hainan, Jiangsu, Gansu, Fujian, Jiangxi, Henan, Hubei, Beijing.
B, Lipontšo li ntse li eketseha.GSK hajoale e na le matšoao a 3 tleliniking.Ka mohlala, matšoao a li-stents a lumelloa feela.Li-heparin tse ling ha li fumanehe.Ts'ebeliso ea bongaka ea li-stents e eketseha ka 30% selemo se seng le se seng.Ka tumello ea lipontšo tse ncha, thekiso e tla eketseha.Ka khopolo, mafu 'ohle a tšoaroang ke lihlahisoa tsa lihlopha tsa heparin a ka phekoloa ke sehlahisoa sena.
C, Theko e molemo, theko e tlaase ea sehlahisoa sena 'marakeng oa US ke lidolara tse 132 tsa US, Chaena ke li-yuan tse 168, theko ea malapeng e ke ke ea theoha.Haeba u reka kantle ho naha, 'maraka oa machabeng o na le sebaka se pharaletseng;
2) Tekanyo ea tekheniki e phahame, thepa e tala e entsoe ka mehato e 75, 'me patent e felile ka lilemo tse 5 (sengoloa sa 2014).Ha e so amoheloe ke bahlahisi ba bang.The synthesis e thata haholo.E ke ke ea etsoa ka tlase ho lilemo tse 10.Potoloho e telele, e thata, ebile e tsetela.hodimo.Ho na le bahlolisani ba seng bakae ba lehae, mme bahlolisani ba kantle ho naha ba na le litšenyehelo tse phahameng tsa thepa e tala.Sepheo sa rona ke ho tsoela pele ho fokotsa litšenyehelo tsa thepa e tala le ho nkela Glaxo sebakeng sa tlhahiso ea thepa e tala.
Hengrui Pharmaceuticals Fondaparinux e amohetsoe e le mohlala oa pele oa ho etsisa China 2018.
Guangdong Runxing Biotechnology Co., Ltd. e na le tlhahiso ea selemo le selemo ea 210 kg ea fondaparinux sodium e tsoetseng pele ea mahareng N3, e tla kenngoa ka 2018.
Fondaparinux qalong e qapiloe ke MYLAN IRELAND.Hajoale, Hengrui Pharmaceuticals, Borui Pharmaceuticals, Haisco.
JIN DUN Medical o na leHo tšoaneleha ha ISO mme e kopana le litekanyetso tsa tlhahiso ea GMP, e hirileng litsebi tsa ka hare ho naha le tsa kantle ho naha tse nang le boiphihlelo bo bongata ho tataisa R&D ea k'hamphani.
THEKNOL OGY MELEMO
● High Pressure Catalytic Hydrogenation .Khatello e Phahameng ea Hydrogenolysis Reaction .Mehato ea Cryogenic (<-78%C)
● Monko o monate oa Heterocyclic Synthesis
● Karabelo ea ho Rulahanya bocha
●Chiral Resolution
●Heck, Suzuki,Negishi,Sonogashira .Giignard Reaction
Thepa
Lab ea rona e na le lisebelisoa tse fapaneng tsa liteko le liteko, joalo ka: NMR (Bruker 400M), HPLC, chiral-HPLC, LC-MS, LC-MS/MS (API 4000), IR, UV, GC, GC-MS, Chromatography, Microwave Synthesizer, Parallel Synthesizer, Differential Scanning Calorimeter (DSC), Electron microscope...
Sehlopha sa R&D
Jindun Medical e na le sehlopha sa basebetsi ba profeshenale ba R&D, 'me e sebelisa litsebi tse ngata tsa lapeng le kantle ho naha ho tataisa R&D, ho etsa hore pokello ea rona e nepahale le ho sebetsa hantle.
Re thusitse lik'hamphani tse ngata tse phahameng tsa malapeng tsa meriana, tse kangHansoh, Hengrui le HEC Pharm.Mona re tla bontša karolo ea bona.
Customization Case One:
Cas No.: 110351-94-5
Taba ea Bobeli ea Tloaelo:
Cas No.: 144848-24-8
Taba ea Boraro ea Tloaelo:
Cas No.: 200636-54-0
1.Iketsetse Li-Intermediate tse Ncha kapa li-API.Joalo ka ho arolelana linyeoe tse kaholimo, bareki ba na le litlhoko tsa li-Intermediates kapa li-API, 'me ha ba khone ho fumana lihlahisoa tse hlokahalang' marakeng, joale re ka thusa ho Customize.
2.Ntlafatso ea Ts'ebetso ea Lihlahisoa tsa Khale.Sehlopha sa rona se tla thusa ho ntlafatsa le ho ntlafatsa tlhahiso e joalo eo tsela ea eona ea ho arabela e leng ea khale, litšenyehelo tsa tlhahiso li phahame, 'me katleho e tlaase.Re ka fana ka litokomane tse felletseng bakeng sa phetisetso ea theknoloji le ntlafatso ea ts'ebetso, re thusa moreki bakeng sa tlhahiso e sebetsang hantle.
Ho tloha ho sepheo sa lithethefatsi ho isa ho INDs, JIN DUN Medical e u falitharollo tsa motho ka mong tsa R&D.
JIN DUN Medical e tsitlallela ho theha sehlopha se nang le litoro, ho etsa lihlahisoa tse nang le seriti, tse hlokolosi, tse thata, le ho tsoa bohle ho ba molekane ea tšepahalang le motsoalle oa bareki!
