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2-butyl-5-nitro-3-benzofuranyl) [4-[3-(dibutylaMino) propoxy]phenyl]

2-butyl-5-nitro-3-benzofuranyl) [4-[3-(dibutylaMino) propoxy]phenyl]

Tlhaloso e Khutšoanyane:

Foromo ea molek'hule: C30H40N2O5

Boima ba molek'hule: 508.65

CASno: 141645-23-0


Lintlha tsa Sehlahisoa

Li-tag tsa Sehlahisoa

Kopo

E sebelisoa ka kliniki ho hyperuricemia ea mantlha le ea bobeli, haholo-holo ho bakuli ba nang le hyperuricemia, hammoho le ho bakuli ba nang le ho se sebetse hantle ha renal, le ho bakuli ba nang le gout e iphetang kapa e sa foleng, hammoho le ho bakuli ba nang le Hyperuricemia.E sebelisoa ho bakuli ba nang le Gouty nephropathy ho imolla matšoao le ho fokotsa sebopeho sa majoe a renal uric acid;majoe a gout;e sebelisoang ho uric acid ea liphio le lefu la liphio la uric acid.

Sethethefatsi se secha sa anti-arrhythmic Atrial fibrillation (AF) ke lefu le ka 'nang la beha bophelo kotsing.Ka lebaka la botsofali ba baahi, liketsahalo tsa lefats'e le lefu la atrial fibrillation li ntse li eketseha, 'me e fetohile mathata a macha a Bophelo bo botle ba sechaba.Ho na le bakuli ba limilione tse 2.5 ba nang le atrial fibrillation United States le limilione tse 4.5 European Union.Ho ea ka lipalo-palo, ho ata ha atrial fibrillation har'a batho ba fetang lilemo tse 30 naheng ea heso ke 0,77%, e ntseng e eketseha ka lilemo, 'me banna ba phahametse basali (0.9%: 0.7%).Mafu a bakang ho ferekana ha atria haholo-holo a akarelletsa khatello ea mali, lefu la pelo, lefu la pelo la valvular, lefu la pelo le sa foleng le sa tloaelehang, le ho hloleha ha pelo.Letšoao le ka sehloohong la bakuli ba nang le atrial fibrillation ke lebelo le sa tloaelehang la ventricular, 'me ho laola lebelo la pelo ho nka boemo bo itseng kalafong e matla le tlhokomelo ea matšoao.Amiodarone e phetha karolo e ntle ea ho laola lebelo la pelo le ho tsosolosa morethetho oa sinus, empa liphello tse mpe tsa litho tse lebisitsoeng tse amanang le karolo ea iodine mohahong oa eona li fokotsa tšebeliso ea eona ea bongaka, e kang tšenyo ea matšoafo, qoqotho le sebete.Liphetoho tse mpe tse boletsoeng ka holimo le sebopeho sa eona The iodine in e amana haufi-ufi.Sethethefatsi se secha sa antiarrhythmic Dronedarone (Dronedarone) se fumanoe ka ho fetola sebopeho sa amiodarone.Dronedarone e na le lisebelisoa tsa electrophysiological tse ts'oanang le amiodarone, empa ha e na iodine ka sebopeho sa eona, kahoo e ka qoba litla-morao tse tebileng tsa extra-cardiac tse bakoang ke iodine Chemicalbook.Dronedarone e ile ea amoheloa bakeng sa ho rekisoa ke US Food and Drug Administration (FDA) ka July 2009, 'me ea amoheloa bakeng sa ho rekisoa European Union ho 2009. Hape ke lithethefatsi tsa pele tse ncha tsa antiarrhythmic tse amoheloang European Union ka lilemo tse 10.Dronedarone ke N-[2-butyl-3-[4-[3-(dibutylamino) propoxy]phenyl] -5-benzofuranyl]-methanesulfonamide, e leng ho fokotsa motsoako oa benzofuran o fumanoang ka ho fetola sebopeho sa amiodarone, e seng karabelo e mpe ea pelo.E tlosa athomo ea iodine ho amiodarone ho fokotsa chefo ea qoqotho le litho tse ling;e eketsa sehlopha sa methylsulfonyl ka lehlakoreng la benzofuran ho fokotsa lipophilicity, kahoo e khutsufatsa halofo ea bophelo ba lithethefatsi le ho fokotsa phello ea ho bokella lisele le monyetla oa lithethefatsi Of neurotoxicity.Ka bobeli 2011 US version le 2010 Europe version ea Atrial Fibrillation Guidelines e khothalletsa dronedarone bakeng sa phekolo ea atrial fibrillation.Dronedarone e bolokehile ebile e sebetsa hantle ho phekola sekhahla sa ventricular le ho boloka sekhahla sa sinus ho bakuli ba fapaneng ntle le AF e matla.E ka ba lithethefatsi tse sebetsang ho nkela amiodarone sebaka.Dronedarone e ka boela ea fokotsa lefu la bakuli ba AF esita le bakuli ba AF ba sa khaotseng.Ka hona, ho lebelletsoe hore e be moriana oa pele ho bakuli ba AF ntle le ho hloleha ho matla ha pelo.Ho feta moo, ts'ebeliso ea li-anticoagulants ho bakuli ba AF ba kotsing e bohareng e na le molemo ho ts'ebeliso ea dronedarone.

Sebelisa:E bohareng bakeng sa Dronedarone hydrochloride
Maemo:maemo a khoebo
Tlhahlobo:≥98%

Kantle:Mokelikeli o mosehla o mafura
Sephutheloana:25kg / moropa

Mohloli o kopantsoeng oa Sehlahisoa

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Setifikeiti

JIN DUN Medical o na leHo tšoaneleha ha ISO mme e kopana le litekanyetso tsa tlhahiso ea GMP, e hirileng litsebi tsa ka hare ho naha le tsa kantle ho naha tse nang le boiphihlelo bo bongata ho tataisa R&D ea k'hamphani.

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Melemo mabapi le ho Itloaetsa Meriana

THEKNOL OGY MELEMO
● High Pressure Catalytic Hydrogenation .Khatello e Phahameng ea Hydrogenolysis Reaction .Mehato ea Cryogenic (<-78%C)
● Monko o monate oa Heterocyclic Synthesis
● Karabelo ea ho Rulahanya bocha
●Chiral Resolution
●Heck, Suzuki,Negishi,Sonogashira .Giignard Reaction

JIN DUN R&D

Thepa

Lab ea rona e na le lisebelisoa tse fapaneng tsa liteko le liteko, joalo ka: NMR (Bruker 400M), HPLC, chiral-HPLC, LC-MS, LC-MS/MS (API 4000), IR, UV, GC, GC-MS, Chromatography, Microwave Synthesizer, Parallel Synthesizer, Differential Scanning Calorimeter (DSC), Electron microscope...

Sehlopha sa R&D

Jindun Medical e na le sehlopha sa basebetsi ba profeshenale ba R&D, 'me e sebelisa litsebi tse ngata tsa lapeng le kantle ho naha ho tataisa R&D, ho etsa hore pokello ea rona e nepahale le ho sebetsa hantle.

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Karolelano ea Nyeoe

Re thusitse lik'hamphani tse ngata tse phahameng tsa malapeng tsa meriana, tse kangHansoh, Hengrui le HEC Pharm.Mona re tla bontša karolo ea bona.

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Customization Case One:

Cas No.: 110351-94-5

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Taba ea Bobeli ea Tloaelo:

Cas No.: 144848-24-8

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Taba ea Boraro ea Tloaelo:

Cas No.: 200636-54-0

Mokhoa oa Tšebelisano

1.Iketsetse Li-Intermediate tse Ncha kapa li-API.Joalo ka ho arolelana linyeoe tse kaholimo, bareki ba na le litlhoko tsa li-Intermediates kapa li-API, 'me ha ba khone ho fumana lihlahisoa tse hlokahalang' marakeng, joale re ka thusa ho Customize.

2.Ntlafatso ea Ts'ebetso ea Lihlahisoa tsa Khale.Sehlopha sa rona se tla thusa ho ntlafatsa le ho ntlafatsa tlhahiso e joalo eo tsela ea eona ea ho arabela e leng ea khale, litšenyehelo tsa tlhahiso li phahame, 'me katleho e tlaase.Re ka fana ka litokomane tse felletseng bakeng sa phetisetso ea theknoloji le ntlafatso ea ts'ebetso, re thusa moreki bakeng sa tlhahiso e sebetsang hantle.

Ho tloha ho sepheo sa lithethefatsi ho isa ho INDs, JIN DUN Medical e u falitharollo tsa motho ka mong tsa R&D.

JIN DUN Medical e tsitlallela ho theha sehlopha se nang le litoro, ho etsa lihlahisoa tse nang le seriti, tse hlokolosi, tse thata, le ho tsoa bohle ho ba molekane ea tšepahalang le motsoalle oa bareki!


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