Casp ungin Acetate;Caspofungin acetate;Cancidas;Caspofungin acetate [USAN:BAN:JAN];
![Casp ungin Acetate;Caspofungin acetate;Cancidas;Caspofungin acetate [USAN:BAN:JAN];Setšoantšo se hlahang](http://cdn.globalso.com/jindunchem-med/fbe17385.jpg)
Casp ungin Acetate;Caspofungin acetate;Cancidas;Caspofungin acetate [USAN:BAN:JAN];
Caspofungin Acetate Biological Activity
| Hlalosa | Caspofungin Acetate ke lithethefatsi tse thibelang likokoana-hloko tse ke keng tsa thibela ka mokhoa o sa tsitsang motsoako oa 1,3-β-d glucan synthase. |
| Tse amananglihlopha | tsela ea pontšo >> Anti-infective >> Fungus Libaka tsa lipatlisiso >> Tšoaetso |
| Ka vivolipatlisiso | Litoeba tse kentsoeng ka caspofungin li ne li se na liphetoho tse kholo ho ERG waveform ea tsona sebakeng sa vitreous concentration ea 0.41 ho 4.1 μM, 'me retina ea bona e ne e se na liphetoho tse bonahalang tsa morphological kapa tahlehelo ea sele.Ka khatello ea vitreous ea 41 μM, caspofungin e fokolitse boholo ba leqhubu, leqhubu la b le karabo ea scotopic ea ERG, hape e bakile ho fokotseha ha palo ea lisele tsa ganglion cell layer [1].Carprofungin (8 mg/kg) kapa amphotericin B 1 mg/kg, ente ea intraperitoneal hanngoe ka letsatsi lihora tse 30 ka mor'a tšoaetso ka matsatsi a 7 a latellanang, ha ho bapisoa le kalafo ea taolo ea koloi, ho phela ka 100% ka letsatsi la 28, ho fella ka sekhahla sa ho shoa ha 100% 11 motšehare. , ka mor'a phephetso ea tšoaetso.Ha ho bapisoa le phekolo ea ho laola koloi ka letsatsi la 5, caspofungin e ile ea fokotsa ho hlaphoheloa ha Candida e sebetsang liphio le lisele tsa boko ha mojaro oa taolo o fihla tlhōrōng ea oona.Litoeba tse tšoaroang ka caspofungin ka tekanyo ea 2 mg / kg kapa holimo li ne li e-na le boima bo fokolang haholo ba boko letsatsing la 5 ho feta litoeba tse tšoaroang ka amphotericin B. Amphotericin B le phekolo ea caspofungin e fokolitse boima ba fungal ea renal ka 1.7 log CFU / g le 2.46 ho 3.64 log CFU /g, ka ho latellana [2]. |
| Phoofoloteko | Phekolo ea antifungal e qalile lihora tse 30 kamora phephetso ea tšoaetso mme ea fanoa ka ente ea intraperitoneal (ip) hang ka letsatsi ka matsatsi a 7.Litoeba li ne li tšoaroa ka 1, 2, 4, kapa 8 mg / kg / letsatsi caspofungin, 1 mg / kg / letsatsi amphotericin B kapa taolo ea koloi (metsi a hloekisitsoeng a sa hloekang).Ho sebetsa ha mohlala ona ho ile ha hlahlojoa ka litsela tse tharo: ka ho shebella lebelo la ho pholoha ha liphoofolo tsa 10 sehlopheng ka seng sa phekolo, ka ho shebella mojaro oa Candida liphio le bokong ba sehlopha sa bobeli sa liphoofolo tse tšoaroang, le ka ho hlahloba liphio ka mokhoa oa histologically.Le boko.Sehlopha sa boraro sa liphoofolo tse tšoaroang.Litoeba li ile tsa matlafatsoa ke CO 2 inhalation le ho etsoa lihora tse 30 (taolo ea koloi feela) le ka letsatsi la 5 (lihora tse 24 ka mor'a tekanyo ea 4), 8 (lihora tse 24 ka mor'a tekanyo ea ho qetela), le 14, lihora tse 21 le histological. sampole ya dithishu.(Kalafo ea caspofungin feela), le 28 ka mor'a tlhaselo. |
| Litšupiso | [1].Mojumder DK, le al.Ho lekola chefo ea retina ea intravitreal caspofungin ka leihlong la toeba.Tsetela Ophthalmol Vis Sci.2010 Nov;51(11):5796-803. [2].Flattery, Amy M. et al.Katleho ea caspofungin ka mohlala oa mocha oa mouse oa tsamaiso ea methapo ea methapo ea candidiasis.Antimicrobial Agents le Chemotherapy (2011), 55 (7), 3491-3497. |
Lik'hemik'hale le thepa ea 'mele ea caspofungin acetate
| Ntho e belang | 1408.1ºC ho 760 mmHg |
| Mokhoa oa limolek'hule | Setšoantšo sa C56H96N10O19 |
| Boima ba molek'hule | 1093.31000 |
| Boleng bo nepahetseng | 1092.64000 |
| PSA | 412.03000 |
| LogP | 0.06150 |
| Litšobotsi tsa ponahalo | bosoeu ho isa ho beige |
| Khatello ea mouoane | 0mmHg ho 25°C |
| Maemo a polokelo | 20°C |
| Ho qhibiliha ha metsi | H2O: soluble15mg/mL (tharollo e hlakileng) |
Litloaelo tsa Caspofungin Acetate
| Melao ea meetlo | 2933990099 |
| Chinese Overview | 2933990099. Metsoako e meng ea heterocyclic e nang le li-heteroatom tsa nitrogen feela.Sekhahla sa lekhetho la boleng bo eketsehileng: 17.0%.Sekhahla sa phokotso ea lekhetho: 13.0%.Maemo a taolo: Ha ho letho.Litefiso tsa naha tse ratoang haholo: 6.5%.Litefiso tse akaretsang: 20.0% |
| Lintlha tsa phatlalatso | Lebitso la sehlahisoa, dikahare tsa motsoako, tšebeliso, hexamethylene chloride, ka kopo bonts'a ponahalo, 6-caprolactam, ka kopo bonts'a ponahalo, letsatsi la ho saena. |
| Kakaretso | 2933990090. metsoako ea heterocyclic e nang le nitrogen hetero-athomo feela.VAT:17.0%.Sekhahla sa phokotso ea lekhetho: 13.0%..Litefiso tsa MFN: 6.5%.Litefiso tse akaretsang: 20.0% |
Mokhoa oa Tlhahiso
Caspofungin e hloka ho lokisoa ka theknoloji ea fermentation semi-synthetic.Sehlahisoa se se nang mahlahahlaha sa selikalikoe se seholo se hloka ho fumanoa ka thekenoloji ea ho belisoa, ebe sehlahisoa se bohareng se fumanoa ka ho arohana le ho hloekisa, ebe sehlahisoa se bohareng se sebelisoa e le thepa ea ho qala ho tlatsa splicing ea mahlakoreng ka ho sebelisa theknoloji ea maiketsetso ho fumana qetellong. the target Element.Hobane "lihlahisoa tse "fermented semi-synthetic" li hloka ho feta har'a lihokelo tse ngata tsa tekheniki tse kang ho belisoa, karohano le tlhoekiso, synthesis, joalo-joalo, tsela ea tekheniki le taolo ea paramethara ea ts'ebetso li rarahane haholo ho Chemicalbook.Ntle le moo, litlhokahalo tsa taolo bakeng sa ngoliso ea caspofungin, sehlahisoa se lomositsoeng sa semi-synthetic, le tsona li phahame haholo.Litokomane tsa kopo li hloka ho qala mohloling oa ho belisoa, eseng feela ho ithuta ka mokhoa o hlophisitsoeng oa temo, theknoloji ea ho belisa, le theknoloji ea tlhoekiso, empa hape le ho hlahloba ts'ebetso ea ho kopanya.Tsela, maemo le taolo ea lits'ila ts'ebetsong, hobane sehlahisoa sa ho qetela se fokola haholo, ho se tsotelle ho fe kapa hofe ho tla hlakola boiteko bohle ba pele, 'me bothata ba tekheniki le litšenyehelo ha li nyane.
Ke ka lebaka la litšitiso tse phahameng tsa tekheniki le sebaka se setle sa tlholisano moo Hengrui Caspofungin e bolokileng sebaka se batlang se le ntle sa theko kamora ho thathamisoa ha eona.
Tšireletso ea patent e felile ka 2014
Ho rekisoa ha liente tsa terminal caspofungin litsing tsa bongaka tsa sechaba tsa China (yuniti: li-yuan tse likete tse leshome)
Ho tla fihlela joale, ke litlhare tse tloaelehileng feela tsa Hengrui Pharmaceuticals, Chia Tai Tianqing, Borui Pharmaceuticals, le Haisco tse amohetsoeng hore li beoe lethathamong.Meriana ea Huadong?
Khamphani ea pele ea lipatlisiso ea caspofungin acetate ke Merck, 'me likopo tsa lethathamo la lik'hamphani tse 6 li ntse li hlahlojoa le ho amoheloa, e leng Qilu Pharmaceutical, Nanjing Yinxing Pharmaceutical, Sihuan Pharmaceutical, Osaikang Pharmaceutical, Sino-US Huadong Pharmaceutical, le Tian Weitical Bio.
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THEKNOL OGY MELEMO
● High Pressure Catalytic Hydrogenation .Khatello e Phahameng ea Hydrogenolysis Reaction .Mehato ea Cryogenic (<-78%C)
● Monko o monate oa Heterocyclic Synthesis
● Karabelo ea ho Rulahanya bocha
●Chiral Resolution
●Heck, Suzuki,Negishi,Sonogashira .Giignard Reaction
Thepa
Lab ea rona e na le lisebelisoa tse fapaneng tsa liteko le liteko, joalo ka: NMR (Bruker 400M), HPLC, chiral-HPLC, LC-MS, LC-MS/MS (API 4000), IR, UV, GC, GC-MS, Chromatography, Microwave Synthesizer, Parallel Synthesizer, Differential Scanning Calorimeter (DSC), Electron microscope...
Sehlopha sa R&D
Jindun Medical e na le sehlopha sa basebetsi ba profeshenale ba R&D, 'me e sebelisa litsebi tse ngata tsa lapeng le kantle ho naha ho tataisa R&D, ho etsa hore pokello ea rona e nepahale le ho sebetsa hantle.
Re thusitse lik'hamphani tse ngata tse phahameng tsa malapeng tsa meriana, tse kangHansoh, Hengrui le HEC Pharm.Mona re tla bontša karolo ea bona.
Customization Case One:
Cas No.: 110351-94-5
Taba ea Bobeli ea Tloaelo:
Cas No.: 144848-24-8
Taba ea Boraro ea Tloaelo:
Cas No.: 200636-54-0
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2.Ntlafatso ea Ts'ebetso ea Lihlahisoa tsa Khale.Sehlopha sa rona se tla thusa ho ntlafatsa le ho ntlafatsa tlhahiso e joalo eo tsela ea eona ea ho arabela e leng ea khale, litšenyehelo tsa tlhahiso li phahame, 'me katleho e tlaase.Re ka fana ka litokomane tse felletseng bakeng sa phetisetso ea theknoloji le ntlafatso ea ts'ebetso, re thusa moreki bakeng sa tlhahiso e sebetsang hantle.
Ho tloha ho sepheo sa lithethefatsi ho isa ho INDs, JIN DUN Medical e u falitharollo tsa motho ka mong tsa R&D.
JIN DUN Medical e tsitlallela ho theha sehlopha se nang le litoro, ho etsa lihlahisoa tse nang le seriti, tse hlokolosi, tse thata, le ho tsoa bohle ho ba molekane ea tšepahalang le motsoalle oa bareki!
