Wholesale Hot Selling Ibrutinib Intermediates N-3 CAS 330792-70-6

Re nahanne ka lepetjo lena, joale re se re le har'a bahlahisi ba nang le boiphihlelo ka ho fetesisa ba thekenoloji, ba theko e tlaase, le ba tlholisano ea litheko bakeng sa Wholesale Hot Selling Ibrutinib Intermediates N-3 CAS 330792-70-6, Re lebelletse ho ho u fa lihlahisoa tsa rona haufinyane, 'me u tla fumana khotheishene ea rona e utloahala haholo mme boleng ba lihlahisoa tsa rona bo ntle haholo!
Re nahanne ka lepetjo lena, joale re se re le har'a bahlahisi ba nang le mekhoa e metle ka ho fetisisa ea theknoloji, ba bolokang chelete e ngata le ba hlōlisanang ka theko.China Ibrutinib N-3 le Intermediates, Ho fihlela joale lihlahisoa tsa rona li se li rometsoe Europe bochabela, Bochabela bo Hare, Boroa-bochabela, Afrika le Amerika Boroa joalo-joalo Re na le 13years thekiso ea litsebi le ho reka ka likarolo tsa Isuzu lapeng le mose ho maoatle le beng ba lisebelisoa tsa morao-rao tsa lisebelisoa tsa elektroniki tsa Isuzu.Re hlompha mosuoe-hlooho oa rona oa Botšepehi khoebong, e tlang pele tšebeletsong 'me re tla etsa sohle seo re ka se khonang ho fa bareki ba rona lihlahisoa tsa boleng bo holimo le tšebeletso e babatsehang.

E bohareng bakeng sa motsoako oa allopurinol.

Ke e 'ngoe ea lihlopha tsa 3-amino-4-substituted pyrazole.E ka sebelisoa e le setsi sa ho kopanya metsoako e mengata e sebetsang ea pharmacologically, e kang allopurinol, e 'ngoe ea li-derivatives tsa pyrazolopyrimidine, ea morao-rao ho tloha ka 1963 Ho tloha ka tšebeliso ea eona ea bongaka, e bile moriana o ka sehloohong oa phekolo ea gout.Hona joale, ho na le mekhoa e fokolang e tsejoang ea ho kopanya

3-aminopyrazole-4-carboxamide hemisulfate Chaena, haholo-holo ka ho itšoara ka malononitrile le triethyl orthoformate ho lokisetsa ethoxymethylene malononitrile, 'me joale ka Karabelo ea hydrazine hydrate e hlahisa 3-amino-4-cyanopyrazole, e qetellang e arabela ka acid e concentrated ho hlahisa sulfuric acid.

3-aminopyrazole-4-carboxamide hemisulfate (Chen Huiru, Xiao Guomin et al. 3-aminopyrazole- Synthesis of 4-formamide hemisulfate [J]. Chemical Industry Times, 2008, 6 (22): 39 40), kakaretso ea lihlahisoa tsa synthesis ka mokhoa ona ke hoo e ka bang 60% (e baloang e le malononitrile), mokhoa ona E kenyelletsa ho itšoara ka mehato e meraro, mehato e telele, 'me li-reagents tse sebelisoang, tse kang malononitrile le ethoxymethylene malononitrile, li na le chefo e ngata ebile li theko e boima.Ho phaella moo, 3-aminopyrazole-4 e lokiselitsoeng ke mokhoa ona - Formamide hemisulfate e na le 'mala o thata ho o tlosa' me o hloka ts'ebetso e eketsehileng, e leng e rarahaneng haholoanyane.

Ho na le litlaleho libukeng tse tsoang linaheng tse ling tse sebelisang pyridylamide hydrazone le ethoxymethylene malononitrile e le lisebelisoa tse tala ho fumana 3-amino-4-cyanopyrazole ka ho phaella le cyclization, ebe o itšoara ka concentrated sulfuric acid ho fumana motsoako o lebisitsoeng (Reuken G Jones. activemethylene metsoako [J] J Am Chem Soc. 1952,74 (5) :4889 4891).Lisebelisoa tse ka sehloohong tse sebelisoang ka mokhoa ona li theko e boima, lihlahisoa tsa karabelo ha li phahame, 'me phaello ea tlhahiso ea indasteri e tlaase.E tlameha ebe ho thata.

Tekanyetso ea tsamaiso:Maemo a Khoebo
Kantle:Phofo e tšoeu kapa e mosehla

Sephutheloana:25kg / moropa
assay (HPLC) litaba tse kholo ho feta kapa li lekana le 98.0%
bohloeki (HPLC) litaba tse kholo ho feta kapa li lekana le 99.5%

JIN DUN Medical o na leHo tšoaneleha ha ISO mme e kopana le litekanyetso tsa tlhahiso ea GMP, e hirileng litsebi tsa ka hare ho naha le tsa kantle ho naha tse nang le boiphihlelo bo bongata ho tataisa R&D ea k'hamphani.

THEKNOL OGY MELEMO
● High Pressure Catalytic Hydrogenation .Khatello e Phahameng ea Hydrogenolysis Reaction .Mehato ea Cryogenic (<-78%C)
● Monko o monate oa Heterocyclic Synthesis
● Karabelo ea ho Rulahanya bocha
●Chiral Resolution
●Heck, Suzuki,Negishi,Sonogashira .Giignard Reaction

Thepa

Lab ea rona e na le lisebelisoa tse fapaneng tsa liteko le liteko, joalo ka: NMR (Bruker 400M), HPLC, chiral-HPLC, LC-MS, LC-MS/MS (API 4000), IR, UV, GC, GC-MS, Chromatography, Microwave Synthesizer, Parallel Synthesizer, Differential Scanning Calorimeter (DSC), Electron microscope…

Sehlopha sa R&D

Jindun Medical e na le sehlopha sa basebetsi ba profeshenale ba R&D, 'me e sebelisa litsebi tse ngata tsa lapeng le kantle ho naha ho tataisa R&D, ho etsa hore pokello ea rona e nepahale le ho sebetsa hantle.

Re thusitse lik'hamphani tse ngata tse phahameng tsa malapeng tsa meriana, tse kangHansoh, Hengrui le HEC Pharm.Mona re tla bontša karolo ea bona.

Customization Case One:

Cas No.: 110351-94-5

Taba ea Bobeli ea Tloaelo:

Cas No.: 144848-24-8

Taba ea Boraro ea Tloaelo:

Cas No.: 200636-54-0

1.Iketsetse Li-Intermediate tse Ncha kapa li-API.Joalo ka ho arolelana linyeoe tse kaholimo, bareki ba na le litlhoko tsa li-Intermediates kapa li-API, 'me ha ba khone ho fumana lihlahisoa tse hlokahalang' marakeng, joale re ka thusa ho Customize.

2.Ntlafatso ea Ts'ebetso ea Lihlahisoa tsa Khale.Sehlopha sa rona se tla thusa ho ntlafatsa le ho ntlafatsa tlhahiso e joalo eo tsela ea eona ea ho arabela e leng ea khale, litšenyehelo tsa tlhahiso li phahame, 'me katleho e tlaase.Re ka fana ka litokomane tse felletseng bakeng sa phetisetso ea theknoloji le ntlafatso ea ts'ebetso, re thusa moreki bakeng sa tlhahiso e sebetsang hantle.

Ho tloha ho sepheo sa lithethefatsi ho isa ho INDs, JIN DUN Medical e u falitharollo tsa motho ka mong tsa R&D.

JIN DUN Medical e tsitlallela ho theha sehlopha se nang le litoro, ho etsa lihlahisoa tse nang le seriti, tse hlokolosi, tse thata, le ho tsoa bohle ho ba molekane ea tšepahalang le motsoalle oa bareki!

Re nahanne ka lepetjo lena, joale re se re le har'a bahlahisi ba nang le boiphihlelo ka ho fetesisa ba thekenoloji, ba theko e tlaase, le ba tlholisano ea litheko bakeng sa Wholesale Hot Selling Ibrutinib Intermediates N-3 CAS 330792-70-6, Re lebelletse ho ho u fa lihlahisoa tsa rona haufinyane, 'me u tla fumana khotheishene ea rona e utloahala haholo mme boleng ba lihlahisoa tsa rona bo ntle haholo!
MorekisiChina Ibrutinib N-3 le Intermediates, Ho fihlela joale lihlahisoa tsa rona li se li rometsoe Europe bochabela, Bochabela bo Hare, Boroa-bochabela, Afrika le Amerika Boroa joalo-joalo Re na le 13years thekiso ea litsebi le ho reka ka likarolo tsa Isuzu lapeng le mose ho maoatle le beng ba lisebelisoa tsa morao-rao tsa lisebelisoa tsa elektroniki tsa Isuzu.Re hlompha mosuoe-hlooho oa rona oa Botšepehi khoebong, e tlang pele tšebeletsong 'me re tla etsa sohle seo re ka se khonang ho fa bareki ba rona lihlahisoa tsa boleng bo holimo le tšebeletso e babatsehang.