1. Liketekete tsa lidolara tsa COVID-19 tsa meriana e tloaelehileng ea India li rekisitsoe?hlokomela!
Haufinyane tjena, sehlooho se mabapi le "COVID-19 Lithethefatsi tse akaretsang tsa India li rekisitsoe ka li-yuan tse likete ka lebokoseng" se hlahile lethathamong le tsebahalang la li-microblog.Lithethefatsi tse ling li ile tsa rekoa molemong oa China News Network, 'me thepa e ne e se e rekisitsoe, kahoo ho ile ha hlokahala hore u li behe beke esale pele.Lingaka li hopotsa hore lithethefatsi ha lia lokela ho rekoa ka mekhoa e sa reroang.Ntle le moo, lihlopha tse seng kotsing e kholo ha li hloke ho sebelisa moriana oa molomo oa COVID-19.
Theko ea mantlha ea lebokose la lithethefatsi ke li-yuan tse 2300, 'me theko ea ho reka India ke li-yuan tse 1600.
Hona joale liodara li se li ngotsoe ka botlalo.Ma-India a 'maloa a rekang lithethefatsi a bolelletse chinanews.com hore lithethefatsi tsa bona tsa Pfizer COVID-19 oral Paxlovid li se li rekisitsoe haufinyane.Haeba ho hlokahala, ba ka lefa depositi feela pele, 'me thepa e ka romelloa ka beke pele ho nako, kapa khoeling e tlang butle haholo.
Haeba mantsoe a reng "COVID-19 India", "COVID-19 generic drug" joalo-joalo a kenyelletsoa sethaleng sa khoebo ea e-commerce, bareki ba ka fumana kapele tlhaiso-leseling ea baemeli bana ba rekang, empa ka kakaretso ba hloka ho eketsa metsoalle ea WeChat, le ebe u tsebisa lintlha tse khethehileng tsa thepa le litlhoko tsa theko.
Lithethefatsi tse akaretsang tsa Paxlovid tse rekisoang ke baemeli bana li kenyelletsa Primovir ka har'a sephutheloana se setala le Paxista ka har'a sephutheloana se putsoa.Ea pele e hlahisoa ke Astrica, k'hamphani ea India, ha ea morao-rao e hlahisoa ke Azista, e leng setsi sa khoebo ea meriana ea India ea Hetero.Hajoale, Primovir e nang le liphutheloana tse tala e emisitse tlhahiso, 'me ke Paxista feela e nang le liphutheloana tse putsoa e ntseng e rekisoa.
Moemeli e mong o ile a hlahisa hore theko ea poso ea lehae e ne e le li-yuan tse 1600 ka lebokoseng le leng, 'me ea mose ho maoatle poso e tobileng e ne e le li-yuan tse 1200 ka lebokose, li-yuan tse 400 ka tlase.Theko ea theko ea Paxlovid Chaena ke li-yuan tse 2300 ka lebokose.
Lithethefatsi tsena tse tloaelehileng ho thata ho li reka setokong hajoale.Ho latela theko ea morekisi e kaholimo, lipeheletso lia amoheleha, 'me mangolo a tobileng a India a tla fihla Chaena ka mor'a matsatsi a 15-20.O boetse a etsa tlhahiso ea hore motho ka mong a ka reka mabokose a mabeli feela.
Lingaka li hopotsa: Ho thata ho khetholla 'nete ho ea bohata.Lula u falimehile
Ebile, Paxlovid esale e sebelisoa kalafong ea ts'oaetso ea COVID-19 Chaena, empa e sebelisoa haholo lipetleleng tse ling tse khethiloeng mme e hloka tumello ea litaelo tsa lingaka.Ha se lipetlele tsohle tse nang le moriana ona.
Ke habohlokoa ho hlokomela hore lithethefatsi tse ling tse tloaelehileng tse rekisoang ka khomishene li ka rekoa ntle le ho fana ka lengolo la ngaka.Tabeng ena, lingaka tsa litsebi li hopotsa bohle hore ba falimehe.
"Joaloka lingaka tse hloahloa, ha re khothaletse ho reka litšoantšo tsa kantle ho naha, hobane ho thata ho khetholla 'nete ho ea bohata."Zhang Jiming, motlatsi oa motsamaisi oa Setsi sa Bongaka sa Naha sa Mafu a tšoaetsanoang le ngaka e ka sehloohong, moprofesa le mookameli oa bongaka ba Sepetlele sa Huashan se ikopantseng le Univesithi ea Fudan, o bolelletse chinanews.com hore ba bang ba bakuli bao a ileng a buisana le bona kapa ba malapa a bona ba ile ba reka litšoantšo ka lekunutu, 'me ba tšoenyehile hore ba reka lithethefatsi tsa fake.O boletse hore ho ne ho le thata ho netefatsa boleng ba litlhare tse tloaelehileng ho tsoa mohloling le maemo a paballo ea litlhare ha u reka litlhare tsa generic ho tsoa kantle ho naha.
Zhang Jiming o phatlalalitse hore moriana oa molomo oa COVID-19 o sebelisoa haholo bakeng sa lihlopha tse kotsing e kholo ho thibela mafu a matla, mme o ka sebetsa ha o sebelisoa pele ho nako.Lihlopha tse seng kotsing e kholo ha li hloke ho potlakela ho reka, 'me tlhekefetso e ka 'na ea baka khanyetso ea lithethefatsi.Hape ha ho hlokahale ho ea ka bongaka, hobane bakuli ba bangata ha ba na matšoao kapa ha ba bonolo, 'me lefu lena le na le moeli.
O ile a bolella chinanews.com hore, mabapi le boemo ba Shanghai, lipetlele tse kholo, lipetlele tse khethiloeng tsa COVID-19 le litsi tse ling tsa bongaka ka kakaretso li na le palo e itseng ea litlhare tse khahlanong le COVID-19, tse sebelisoang ke lihlopha tse kotsing e kholo tse kopanang le matšoao 'me li le teng. e tšoaelitsoe ke COVID-19, molemong oa ho thibela mafu a matla le ho fokotsa sekhahla sa batho ba shoang.
Ntle le moo, ho latela litlaleho tsa mecha ea litaba, basebetsi ba molao ba hopotsa hore lithethefatsi tsa generic tsa India COVID-19 tse rekisoang inthaneteng ha li so amoheloe China.Tlas'a Molao oa hajoale oa Tsamaiso ea Lithethefatsi oa Rephabliki ea Batho ea Chaena, le hoja lithethefatsi tse thathamisitsoeng linaheng tse ling empa li e-s'o amoheloe Chaena li se li sa tsejoe feela e le lithethefatsi tsa bohata, basebetsi ba ntse ba tla tobana le likotlo tsa tsamaiso bakeng sa ho romelloa ha lithethefatsi ka ntle ho molao.
2.Xinlitai o tsamaile!Ho tšoara mefuta e 'meli ea limilione tse likete tse 1, mefuta e 11 ea lithethefatsi tse ncha tsa Sehlopha sa 1.
Haufinyane tjena, phaephe ea Xinlitai R&D e entse tsoelo-pele e ncha.Lipilisi tse ncha tsa sehlopha sa 1 sa SAL0133 li kentsoe tšebeliso ea bongaka.Liphetho tsa tlhahlobo ea lipalo-palo tsa pele li fumanoe tekong ea bongaka ea Phase Ib ea PCSK9 antibody ea monoclonal.Ho tloha ka 2022, Xinlitai e kentse kopo ea IND/NDA bakeng sa lithethefatsi tse 7 tse ncha, 'me lipatlisiso le nts'etsopele ea boqapi li ntse li khothaletsoa butle-butle.Hona joale, Xinlitai e na le mefuta e 'meli ea libilione tse 1, tse 22 tsa tsona li hlahlobiloe (8 ke tsa pele);Litlhare tse 21 tse ncha li ntse li etsoa lipatlisiso, tse 6 tsa tsona li maemong a bongaka a NDA kapa Phase III, 'me lipeipi tsa boiqapelo li kene nakong ea chelete.
Kalafo e pharalletseng ea COVID-19 ea Oral ea Hlahisa!Xinlitai e Kena Potolohong ea COVID-19
Ka la 20 Tšitoe, Xinlitai o phatlalalitse hore ts'ebeliso ea bongaka ea SAL0133, e leng sethethefatsi se senyenyane sa molek'hule se ikemetseng se ntlafalitsoeng ke k'hamphani, se amohetsoe ke Tsamaiso ea Naha ea Lijo le Lithethefatsi.SAL0133 ke inhibitor e matla, e pharalletseng e khahlano le novel coronavirus 3CL protease (3CLpro) e iqapetsoeng le ho ntlafatsoa ke k'hamphani e nang le litokelo tse ikemetseng tsa thepa ea mahlale.Hajoale, sesupo sa tleliniki se lokelang ho ntlafatsoa ke ho phekola pneumonia ea batho ba baholo e bobebe/e tloaelehileng (COVID-19).
3CLpro e bapala karolo ea bohlokoa phetisong ea RNA ea "coronavirus" e ncha, haholo-holo mohatong oa pele oa ho ikatisa ka mor'a hore vaerase e kene ka seleng e amohelang, e thibela tšebetso ea 3CLpro protease, e ka thibelang ho ikatisa ha vaerase ka nepo le ho fihlela karolo ea anti novel coronavirus.
SAL0133 e na le mokhoa o hlakileng oa ts'ebetso, 'me e na le phello e matla, e pharaletseng ea anti-COVID-19.Ho lebeletsoe hore ha ho hlokahale hore e kopane le CYP3A4 inhibitor ritonavir, 'me kotsi e ka bang teng ea ho sebelisana le lithethefatsi e tlaase;Ho lebelletsoe ho fihlella ts'ebeliso ea lithethefatsi tse le 'ngoe hang ka letsatsi le ho ntlafatsa ho latela melao ea mokuli.Haeba e ka ntlafatsoa ka katleho le ho amoheloa bakeng sa ho bapatsa, e tla fa bakuli likhetho tse ncha tsa lithethefatsi ho fihlela litlhoko tse sa fihlelleheng tsa kliniki.
Patlisiso le nts'etsopele ea litlhare tsa molek'hule tse nyane tsa 3CL tse khahlano le COVID-19 li hohetse tlhokomelo e kholo.Hajoale, ke Pfizer's Paxlovid feela e amohetsoeng bakeng sa ho bapatsa lefatšeng.Likhoebo tse fetang 10 tsa malapeng tsa meriana le litsi tsa lipatlisiso tsa mahlale li ntse li etsa lipatlisiso le nts'etsopele ea litlhare tse 3CL tse reretsoeng ho thibela COVID-19, ho kenyeletsoa FB2001 ea Frontier Biology, VV993 ea Junshi Biology/Wangshan Wangshui, SIM0417 ea Pioneer Pharmaceutical, RAY1216 Pharmaceutical tablets GST-HG171 ea Guangshengtang, joalo-joalo.
Ka mefuta e 2 e meholo ea 1 bilione, lithethefatsi tse 7 tse ncha selemong sena li amohela tsoelo-pele e ncha
Ho elella bofelong ba 2022, e le moemeli ea tloaelehileng oa phetoho ea R & D indastering ea meriana, Xinlitai e atlehile ho fumana tsela ea eona ea ntlafatso e ncha tlas'a khatello le tokiso.
Likarolong tse tharo tsa pele tsa 2022, lekeno la k'hamphani e ne e le li-yuan tse limilione tse likete tse 2.548, ka kholo ea selemo le selemo ea 16.5%, 'me phaello ea eona e ne e le li-yuan tse limilione tse 539, ka kholo ea selemo le selemo ea 37.64%.Tshebetso e ntle e ile ya rala motheo o tiileng bakeng sa ntshetsopele e latelang.Khampani e lebeletse hore ka 2022, Taijia (clopidogrel bisulfate tablet) e tla fumana chelete e ka bang li-yuan tse limilione tse likete tse 1, 'me Sinritan (alisartan tablet) e tla fumana chelete e ka bang limilione tse 900 ho isa ho li-yuan tse limilione tse likete.Khamphani e na le mefuta e 22, e 8 ea eona ke ea pele Chaena.
Ka selemo sa 2019, mofuta o ka sehloohong oa Xinlitai, Taijia, o ile oa lahleheloa ke tefiso ea ona molemong oa theko e bohareng ea 4+7, e ileng ea qobella Xinlitai ho etsa liphetoho.Tlalehong ea selemo ea 2019, Xinlitai o phatlalalitse hore "peipi ea lipatlisiso e tla ntlafatsoa ka leano, 'me merero ea anti-tumor biological analog le lithibela-mafu methating e meng ea bongaka e tla felisoa".Ka 2020, e le ho tsoela pele ho ntlafatsa lipeipi tlas'a lipatlisiso le ho tsepamisa maikutlo ho R&D le ho phahamisa lihlahisoa tse ncha, Xinlitai e ile ea fetisetsa litokelo le lithahasello tse amehang tsa dapoxetine hydrochloride, erlotinib hydrochloride, rivasaban le merero e meng, 'me ea fumana tefiso ea phetisetso.
Kamora liphetoho tse ling, hajoale, phala ea lithethefatsi tse akaretsang tsa Xinritai e na le ts'ebeliso ea papatso ea Sehlopha sa 4 feela bakeng sa ho etsisa matlapa a sodium a Sakubatrovalsartan a ntseng a hlahlojoa, le ts'ebeliso ea tlatsetso ea tlhahlobo e tsitsitseng ea cefuroxime sodium bakeng sa ente le cefotaxime sodium bakeng sa ente e ntseng e hlahlojoa.Ho bohlokoa ho bolela hore ho tloha ka Phupu 2019, Xinlitai ha e so ka e etsa kopo ea litlhare tse ncha ka lilemo tse fetang tse 3, mme e tsepamisitse maikutlo holima boqapi le lipatlisiso.
Ho tloha ka 2022, Xinlitai e hatetse pele ho etsa lipatlisiso le nts'etsopele ea lithethefatsi tse ncha.Ka la 4 Pherekhong 2022, ts'ebeliso ea lethathamo la matlapa a CINRITAI a HIF-PHI inhibitor Enasitar e entsoe ke CDE;Ka mor'a moo, Khampani e ile ea kenya likopo tsa kliniki bakeng sa meriana e mehlano e mecha ea Sehlopha sa 1, e leng, recombinant human neuromodulin-1 anti HER3 antibody fusion protein injection, SAL0112 tablet, SAL008 injection, SAL0119 tablets le SAL0133 tablet;Ka la 3 Pulungoana, sehlopha se secha sa 2.3 se ntlafalitse lipilisi tsa alisartan le amlodipine tsa SINRITAI li ile tsa kenya kopo ea ho thathamisa, e lebeletsoeng ho theha synergy ea leano le sehlopha se thathamisitsoeng sa 1.1 sa lithethefatsi tse thibelang khatello ea mali SINRITAI.
JinDun Medicale na le tšebelisano-'moho ea nako e telele ea lipatlisiso tsa mahlale le theknoloji ea ho hlomathisa le liunivesithi tsa China.Ka lisebelisoa tse ngata tsa bongaka tsa Jiangsu, e na le likamano tsa nako e telele tsa khoebo le India, Asia Boroa-bochabela, Korea Boroa, Japane le limmaraka tse ling.E boetse e fana ka lits'ebeletso tsa mebaraka le thekiso ts'ebetsong eohle ho tloha bohareng ho isa ho API ea sehlahisoa se felileng.Sebelisa lisebelisoa tse bokelletsoeng tsa Yangshi Chemical k'hemistri ea fluorine ho fana ka lits'ebeletso tse khethehileng tsa ho etsa lik'hemik'hale bakeng sa balekane.Fana ka lits'ebeletso tsa boiqapelo le lits'ebeletso tsa lipatlisiso tsa litšila ho lebisa bareki.
JinDun Medical e tsitlallela ho theha sehlopha se nang le litoro, ho etsa lihlahisoa tse nang le seriti, tse hlokolosi, tse thata, 'me li tsoele pele ho ba molekane ea tšeptjoang le motsoalle oa bareki! setsebitlhahiso ea meriana e hlophisitsoeng(CMO) le bafani ba litšebeletso tsa R&D le tlhahiso ea meriana e ikhethileng (CDMO).Jindun e tla u felehetsa ho ea qeta COVID-19.
Nako ea poso: Jan-28-2023