L-Valine e sebelisoa joalo ka bohareng ba Valaciclovir.
Valacyclovir ke guanine analogue antiviral sethethefatsi.E sebelisoa ho phekola tšoaetso ea herpes simplex le herpes zoster mafu a tšoaetsanoang ka thobalano.Sehlahisoa sena ke selelekela sa acyclovir.E kenngoa ka potlako ka mor'a ho tsamaisoa ka molomo 'me ka potlako e fetoloa ho ba acyclovir' meleng.Tšusumetso ea eona ea antiviral e bapaloa ke acyclovir.Ka mor'a hore acyclovir e kene liseleng tse nang le tšoaetso ea herpes, e hlōlisana le deoxynucleoside bakeng sa kokoana-hloko thymidine deoxynucleoside kinase kapa cell kinase, 'me moriana o phosphorylated ho activated acyclic guanosine triphosphate.E le karolo e ka tlaase ea ho ikatisa ha kokoana-hloko, acyclovir e qothisana lehlokoa le deoxyguanine triphosphate bakeng sa kokoana-hloko ea DNA polymerase, e thibelang motsoako oa DNA ea kokoana-hloko le ho bontša phello ea antiviral.Ts'ebetso ea antiviral ea sehlahisoa sena ka vivo e betere ho feta acyclovir, mme index ea kalafo ea herpes simplex kokoana-hloko ea mofuta oa I le mofuta oa II ke 42.91% le 30.13% e phahameng ho feta acyclovir.E boetse e na le phello e phahameng ea phekolo ho varicella zoster virus.
JIN DUN Medical o na leHo tšoaneleha ha ISO mme e kopana le litekanyetso tsa tlhahiso ea GMP, e hirileng litsebi tsa ka hare ho naha le tsa kantle ho naha tse nang le boiphihlelo bo bongata ho tataisa R&D ea k'hamphani.
THEKNOL OGY MELEMO
● High Pressure Catalytic Hydrogenation .Khatello e Phahameng ea Hydrogenolysis Reaction .Mehato ea Cryogenic (<-78%C)
● Monko o monate oa Heterocyclic Synthesis
● Karabelo ea ho Rulahanya bocha
●Chiral Resolution
●Heck, Suzuki,Negishi,Sonogashira .Giignard Reaction
Thepa
Lab ea rona e na le lisebelisoa tse fapaneng tsa liteko le liteko, joalo ka: NMR (Bruker 400M), HPLC, chiral-HPLC, LC-MS, LC-MS/MS (API 4000), IR, UV, GC, GC-MS, Chromatography, Microwave Synthesizer, Parallel Synthesizer, Differential Scanning Calorimeter (DSC), Electron microscope...
Sehlopha sa R&D
Jindun Medical e na le sehlopha sa basebetsi ba profeshenale ba R&D, 'me e sebelisa litsebi tse ngata tsa lapeng le kantle ho naha ho tataisa R&D, ho etsa hore pokello ea rona e nepahale le ho sebetsa hantle.
Re thusitse lik'hamphani tse ngata tse phahameng tsa malapeng tsa meriana, tse kangHansoh, Hengrui le HEC Pharm.Mona re tla bontša karolo ea bona.
Customization Case One:
Cas No.: 110351-94-5
Taba ea Bobeli ea Tloaelo:
Cas No.: 144848-24-8
Taba ea Boraro ea Tloaelo:
Cas No.: 200636-54-0
1.Iketsetse Li-Intermediate tse Ncha kapa li-API.Joalo ka ho arolelana linyeoe tse kaholimo, bareki ba na le litlhoko tsa li-Intermediates kapa li-API, 'me ha ba khone ho fumana lihlahisoa tse hlokahalang' marakeng, joale re ka thusa ho Customize.
2.Ntlafatso ea Ts'ebetso ea Lihlahisoa tsa Khale.Sehlopha sa rona se tla thusa ho ntlafatsa le ho ntlafatsa tlhahiso e joalo eo tsela ea eona ea ho arabela e leng ea khale, litšenyehelo tsa tlhahiso li phahame, 'me katleho e tlaase.Re ka fana ka litokomane tse felletseng bakeng sa phetisetso ea theknoloji le ntlafatso ea ts'ebetso, re thusa moreki bakeng sa tlhahiso e sebetsang hantle.
Ho tloha ho sepheo sa lithethefatsi ho isa ho INDs, JIN DUN Medical e u falitharollo tsa motho ka mong tsa R&D.
JIN DUN Medical e tsitlallela ho theha sehlopha se nang le litoro, ho etsa lihlahisoa tse nang le seriti, tse hlokolosi, tse thata, le ho tsoa bohle ho ba molekane ea tšepahalang le motsoalle oa bareki!