Guanosine

Guanosine e sebelisoa e le bohareng ba Valaciclovir.
Valacyclovir ke guanine analogue antiviral sethethefatsi.E sebelisoa ho phekola tšoaetso ea herpes simplex le herpes zoster mafu a tšoaetsanoang ka thobalano.Sehlahisoa sena ke selelekela sa acyclovir.E kenngoa ka potlako ka mor'a ho tsamaisoa ka molomo 'me ka potlako e fetoloa ho ba acyclovir' meleng.Tšusumetso ea eona ea antiviral e bapaloa ke acyclovir.Ka mor'a hore acyclovir e kene liseleng tse nang le tšoaetso ea herpes, e hlōlisana le deoxynucleoside bakeng sa kokoana-hloko thymidine deoxynucleoside kinase kapa cell kinase, 'me moriana o phosphorylated ho activated acyclic guanosine triphosphate.E le karolo e ka tlaase ea ho ikatisa ha kokoana-hloko, acyclovir e qothisana lehlokoa le deoxyguanine triphosphate bakeng sa kokoana-hloko ea DNA polymerase, e thibelang motsoako oa DNA ea kokoana-hloko le ho bontša phello ea antiviral.Ts'ebetso ea antiviral ea sehlahisoa sena ka vivo e betere ho feta acyclovir, mme index ea kalafo ea herpes simplex kokoana-hloko ea mofuta oa I le mofuta oa II ke 42.91% le 30.13% e phahameng ho feta acyclovir.E boetse e na le phello e phahameng ea phekolo ho varicella zoster virus.