4-Methoxybenzylalkohol;ANISALKOHOL;4-methoxy-benzenemethano;

E bohareng bakeng sa Moxonidine
E ka hlasimolla li-receptor tse bohareng tsa α2 mme ea baka litlamorao tsa antihypertensive, tse ts'oanang le clonidine.Sekhahla sa ho monya ka molomo (90%) le bioavailability (88%) ka bobeli li holimo, 'me ha ho na phello ea pele ea ho feta.Tlhōrō ea khatello ea mali e hlaha lihora tse 1 ho isa ho tse 3 ka mor'a ho noa moriana.Boholo ba eona bo ntšoa ke liphio.T1/2 e ka ba lihora tse peli.Clinically sebediswa bakeng sa kgatelelo ya madi.

Mokelikeli o se nang mmala kapa o mosehla hanyane.Sebaka se qhibilihisang ke 23-25.5 ° C, ntlha e belang ke 159 ° C, tekanyo e lekanyelitsoeng ke 1.113 (15/15 ° C), 'me index ea refractive ke 1.5442.E qhibiliha ha bonolo joala le ether, e batla e sa qhibilihe metsing.

Sehlahisoa sena se na le monko o monate oa fennel hanyenyane 'me hangata se sebelisoa ha ho lokisoa jasmine, lilac le litlolo tse ling,' me se loketse ho lokisoa ha litlolo tse nkhang hamonate.Sehlahisoa sena ke senoko se jeoang se lumelletsoeng ke GB2760-86 ea naha ea heso.Haholo-holo e sebelisoa ho lokisa litatso tse kang vanila, chokolete, cocoa, almonde le perekisi.E boetse e sebelisoa ho organic synthesis le joalo ka solvent.

Ka ho fokotseha ha anisaldehyde.Cannizzaro e sebetsana le anise, formaldehyde le sodium hydroxide ka har'a ethanol ho hlahisa joala ba p-methoxybenzyl.

Ka mor'a hore ethanol e fumanehe ka distillation, karolo ea oli e fumanoeng ke karabelo e ntšoa ka benzene, e tšeloa ka acetic acid, ebe e kenngoa ka sodium bicarbonate ho alkaline e fokolang.Ka mor'a ho hlatsuoa ka metsi ho ea ho se nke lehlakore, benzene e khutlisetsoa ka ho tšeloa, 'me e setseng e kenngoa ka vacuum distillation ho fumana p-methoxy Benzyl joala.

E sebetsa ka ho susumetsa li-presynaptic α2-receptors tse bohareng.Tšusumetso ea eona ea antihypertensive e tšoana le ea mohanyetsi oa calcium nifedipine le ACE inhibitor captopril.E sebelisoa bakeng sa khatello e phahameng ea mali.